ACUTE IZONIAZID POISONING WITH PRESENTATION OF A CLINICAL CASE

ACUTE IZONIAZID POISONING WITH PRESENTATION OF A CLINICAL CASE

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Rimicid or isonide a group of medications which belong to anti-tuberculosis medicaments.The active substance isoniazid is used to treat pulmonary and extrapulmonary forms of tuberculosis, as well as prophylaxis in case of contact with infected individuals.Isoniazid is rapidly absorbed, reaching a maximum serum concentration in 2 hours, and penetrates all body fluids.The volume of distribution is approximately 0.6 l/kg.

Isoniazid causes pyridoxine deficiency in two ways: - by hydrazones, isoniazid metabolites inhibit the pyridoxal hiboost 4k smart link kinase, which converts pyridoxine to the active form, pyridoxal-5-phosphate, and - pyridoxine deficiency disrupts the synthesis and metabolism of GABA, the main inhibitory mediator of the 15-eg1053cl central nervous system.Isonicotinic acid poisoning metabolism is subject to individualized factors, and in some people, this metabolism can be in a significantly slower.A clinical case of poisoning with 30 tablets of Rimicid by a 16-year-old girl suicidal attempt was presented.The results of the TC analysis confirm intoxication with the drug, and the retrospective assessment of the concentration over a past period of time using the elimination half-life has revealed an extremely high dose of ingested isoniazid.